Polymorph selection: Challenges for the future?

被引：193

作者：

Blagden, N ^{[1
]}

Davey, RJ

机构：

[1] Univ Bradford, Sch Pharm, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England

[2] Univ Manchester, Dept Chem Engn, Mol Mat Ctr, Manchester M60 1QD, Lancs, England

来源：

CRYSTAL GROWTH & DESIGN | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1021/cg030025k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This contribution reviews the area of polymorph selection during solution crystallization using known and predicted structures. In particular, an overview of what has been learned about the relationship between structure and kinetics and of the interplay between thermodynamics and kinetics is presented. This review adds to the debate by discussing the future challenges that we envisage in realizing polymorph selection as a crystal engineering exercise by highlighting the role that a packing landscape approach may contribute in manipulating the selection of a polymorph.

引用

页码：873 / 885

页数：13

共 23 条

[1] DECODING HYDROGEN-BOND PATTERNS - THE CASE OF IMINODIACETIC ACID [J].

BERNSTEIN, J ;

ETTER, MC ;

MACDONALD, JC .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1990, (05) :695-698

[2]

BEYER T, 2001, CRYSTENGCOMM, V44, P1

[3] Crystal chemistry and solvent effects in polymorphic systems - Sulfathiazole [J].

Blagden, N ;

Davey, RJ ;

Lieberman, HF ;

Williams, L ;

Payne, R ;

Roberts, R ;

Rowe, R ;

Docherty, R .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS, 1998, 94 (08) :1035-1044

[4] Can crystal structure prediction be used as part of an integrated strategy for ensuring maximum diversity of isolated crystal forms? The case of 2-amino-4-nitrophenol [J].

Blagden, N ;

Cross, WI ;

Davey, RJ ;

Broderick, M ;

Pritchard, RG ;

Roberts, RJ ;

Rowe, RC .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2001, 3 (17) :3819-3825

[5]

BLAGDEN N, 2003, JCGD, V3, P197

[6]

CARDEW PT, 1993, FARADAY DISCUSS, V95, P160

[7]

CROSS W, 2003, JCGD, V3, P151

[8] Crystal engineering - nucleation, the key step [J].

Davey, RJ ;

Allen, K ;

Blagden, N ;

Cross, WI ;

Lieberman, HF ;

Quayle, MJ ;

Righini, S ;

Seton, L ;

Tiddy, GJT .

CRYSTENGCOMM, 2002, 4 :257-264

[9] Polymorphism in molecular crystals: Stabilization of a metastable form by conformational mimicry [J].

Davey, RJ ;

Blagden, N ;

Potts, GD ;

Docherty, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (07) :1767-1772

[10] Nucleation control in solution mediated polymorphic phase transformations: The case of 2,6-dihydroxybenzoic acid [J].

Davey, RJ ;

Blagden, N ;

Righini, S ;

Alison, H ;

Ferrari, ES .

JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (08) :1954-1959

← 1 2 3 →