Wilms' tumour: Connecting tumorigenesis and organ development in the kidney

被引：263

作者：

Rivera, MN ^{[1
]}

Haber, DA

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

[3] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[4] Brigham & Womens Hosp, Boston, MA 02114 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 09期

关键词：

D O I：

10.1038/nrc1696

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Wilms' tumour, or nephroblastoma, is a common childhood tumour that is intimately linked to early kidney development and is often associated with persistent embryonic renal tissue and other kidney abnormalities. WT1, the first gene found to be inactivated in Wilms' tumour, encodes a transcription factor that functions as both a tumour suppressor and a critical regulator of renal organogenesis. Our understanding of the roles of WT1 in tumour formation and organogenesis have advanced in parallel, providing a striking example of the intersection between tumour biology, cellular differentiation and normal organogenesis.

引用

页码：699 / 712

页数：14

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