Intramolecular direct arylation in the synthesis of fluorinated carbazoles

被引：60

作者：

Bedford, Robin B. ^{[1
]}

Betham, Michael ^{[1
]}

Charmant, Jonathan P. H. ^{[1
]}

Weeks, Amanda L. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

TETRAHEDRON | 2008年 / 64卷 / 26期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/j.tet.2008.01.143

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The amination of 2-chloroanilines with aryl bromides and subsequent intramolecular direct arylation can be exploited in the synthesis of a range of fluorinated carbazoles, where the fluorine substituent can be introduced via the aniline, the aryl bromide or both substrates. Depending on substitution patterns, the two steps can either be per-formed in tandem in one-pot under microwave heating conditions or else require a two pot approach. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6038 / 6050

页数：13

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