RETRACTED: A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer (Retracted Article)

被引：37

作者：

Yang, Xiao Yi ^{[2
]}

Wang, Li Hua ^{[2
]}

Farrar, William L. ^{[1
]}

机构：

[1] NCI, Canc Stem Cell Sect, Lab Canc Prevent, Div Basic Sci, Frederick, MD 21702 USA

[2] NCI, Basic Res Program, SAIC Frederick, Frederick, MD 21702 USA

来源：

PPAR RESEARCH | 2008年 / 2008卷

关键词：

D O I：

10.1155/2008/961753

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPAR. and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPAR. on metabolism and cellular differentiation, abundant evidence suggests that PPAR. is an important regulator of the immune system and cancers. Since cytokines are not only key modulators of inflammation with pro-and anti-inflammatory functions but they also can either stimulate or inhibit tumor growth and progression, this review summarizes the role for PPAR. in the regulation of cytokine production and cytokine-mediated signal transduction pathways in immune cells and cancer. Copyright (C) 2008 Xiao Yi Yang et al.

引用

页数：12

共 115 条

[1]

A road map for those who don't know JAK-STAT [J].

Aaronson, DS ;

Horvath, CM .

SCIENCE, 2002, 296 (5573) :1653-1655

[2]

Functional diversity of helper T lymphocytes [J].

Abbas, AK ;

Murphy, KM ;

Sher, A .

NATURE, 1996, 383 (6603) :787-793

[3]

Targeted therapy of multiple myeloma based upon tumor-microenvironmental interactions [J].

Anderson, Kenneth C. .

EXPERIMENTAL HEMATOLOGY, 2007, 35 (04) :155-162

[4]

STEROID-HORMONE RECEPTORS - MANY ACTORS IN SEARCH OF A PLOT [J].

BEATO, M ;

HERRLICH, P ;

SCHUTZ, G .

CELL, 1995, 83 (06) :851-857

[5]

Th17: the third member of the effector T cell trilogy [J].

Bettelli, Estelle ;

Korn, Thomas ;

Kuchroo, Vijay K. .

CURRENT OPINION IN IMMUNOLOGY, 2007, 19 (06) :652-657

[6]

TH-17 cells in the circle of immunity and autoimmunity [J].

Bettelli, Estelle ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE IMMUNOLOGY, 2007, 8 (04) :345-350

[7]

Nuclear receptor ligand-binding domains three-dimensional structures, molecular interactions and pharmacological implications [J].

Bourguet, W ;

Germain, P ;

Gronemeyer, H .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2000, 21 (10) :381-388

[8]

Brown MA, 1997, CRIT REV IMMUNOL, V17, P1

[9]

Butler R, 2000, CELL GROWTH DIFFER, V11, P49

[10]

Chang TH, 2000, CANCER RES, V60, P1129

← 1 2 3 4 5 6 7 8 9 10 →