B-MYB, a transcription factor implicated in regulating cell cycle, apoptosis and cancer

被引：119

作者：

Sala, A ^{[1
]}

机构：

[1] Inst Child Hlth, Mol Haematol & Canc Biol Unit, London WC1N 1EH, England

来源：

EUROPEAN JOURNAL OF CANCER | 2005年 / 41卷 / 16期

关键词：

MYB; E2F; retinoblastoma; cell cycle; BC12; clusterin; apoptosis; neuroblastoma;

D O I：

10.1016/j.ejca.2005.08.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B-MYB belongs to the MYB family of transcription factors that include A-MYB and c-MYB. While A-MYB and c-MYB are tissue-specific, B-MYB is broadly expressed in rapidly dividing cells of developing or adult mammals. B-MYBs liaisons with important players of the cell cycle and transcription machinery, such as E2F and retinoblastoma proteins, suggest that its essential function in stem cell formation and mammalian development could be related to its ability to directly or indirectly impinge on gene expression. Besides its role in the cell cycle, B-MYB has been shown to promote cell survival by activating antiapoptotic genes such as ApoJ/clusterin and BCL2. Here, we discuss how B-MYB could be implicated in tumourigenesis by regulating gene expression. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2479 / 2484

页数：6

共 65 条

[1] DOMINANT INTERFERING ALLELES DEFINE A ROLE FOR C-MYB IN T-CELL DEVELOPMENT [J].

BADIANI, P ;

CORBELLA, P ;

KIOUSSIS, D ;

MARVEL, J ;

WESTON, K .

GENES & DEVELOPMENT, 1994, 8 (07) :770-782

[2]

Bar-Shira A, 2002, CANCER RES, V62, P6803

[3] Critical functions for c-Myb at three checkpoints during thymocyte development [J].

Bender, TP ;

Kremer, CS ;

Kraus, M ;

Buch, T ;

Rajewsky, K .

NATURE IMMUNOLOGY, 2004, 5 (07) :721-729

[4] Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator [J].

Bessa, M ;

Saville, MK ;

Watson, RJ .

ONCOGENE, 2001, 20 (26) :3376-3386

[5]

BIES J, 1995, CANCER RES, V55, P501

[6] Direct transactivation of the anti-apoptotic gene apolipoprotein J (Clusterin) by B-MYB [J].

Cervellera, M ;

Raschella, G ;

Santilli, G ;

Tanno, B ;

Ventura, A ;

Mancini, C ;

Sevignani, C ;

Calabretta, B ;

Sala, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (28) :21055-21060

[7] Degradation of B-Myb by ubiquitin-mediated proteolysis:: involvement of the Cdc34-SCFp45Skp2 pathway [J].

Charrasse, S ;

Carena, I ;

Brondani, V ;

Klempnauer, KH ;

Ferrari, S .

ONCOGENE, 2000, 19 (26) :2986-2995

[8] Functional evolution of the vertebrate Myb gene family:: B-Myb, but neither A-Myb nor C-Myb, complements drosophila Myb in hemocytes [J].

Davidson, CJ ;

Tirouvanziam, R ;

Herzenberg, LA ;

Lipsick, JS .

GENETICS, 2005, 169 (01) :215-229

[9] Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb [J].

Emambokus, N ;

Vegiopoulos, A ;

Harman, B ;

Jenkinson, E ;

Anderson, G ;

Frampton, J .

EMBO JOURNAL, 2003, 22 (17) :4478-4488

[10]

Forozan F, 2000, CANCER RES, V60, P4519

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