A novel isoform of the Ly108 gene ameliorates murine lupus

被引：46

作者：

Keszei, Marton ^{[1
]}

Detre, Cynthia ^{[1
]}

Rietdijk, Svend T. ^{[1
]}

Munoz, Pilar ^{[2
]}

Romero, Xavier ^{[1
]}

Berger, Scott B. ^{[1
]}

Calpe, Silvia ^{[1
]}

Liao, Gongxian ^{[1
]}

Castro, Wilson ^{[1
]}

Julien, Aimee ^{[1
]}

Wu, Ying-Yu ^{[1
]}

Shin, Dong-Mi ^{[3
]}

Sancho, Jaime ^{[2
]}

Zubiaur, Mercedes ^{[2
]}

Morse, Herbert C., III ^{[3
]}

Morel, Laurence ^{[4
]}

Engel, Pablo ^{[5
]}

Wang, Ninghai ^{[1
]}

Terhorst, Cox ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Div Immunol, Dept Med,Med Sch, Boston, MA 02115 USA

[2] CSIC, Inst Parasitol & Biomed, Granada 18100, Spain

[3] NIAID, Immunopathol Lab, NIH, Rockville, MD 20852 USA

[4] Univ Florida, Coll Med, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA

[5] Univ Barcelona, Sch Med, Dept Cellular Biol & Pathol, Immunol Unit, E-08036 Barcelona, Spain

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2011年 / 208卷 / 04期

基金：

美国国家卫生研究院;

关键词：

SPLICED 3'-UNTRANSLATED REGION; B-CELL TOLERANCE; SPONTANEOUS AUTOIMMUNITY; SUSCEPTIBILITY LOCI; C57BL/6; MICE; TCR-ZETA; T-CELLS; ERYTHEMATOSUS; FAMILY; EXPRESSION;

D O I：

10.1084/jem.20101653

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Studies of human systemic lupus erythematosus patients and of murine congenic mouse strains associate genes in a DNA segment on chromosome 1 with a genetic predisposition for this disease. The systematic analysis of lupus-prone congenic mouse strains suggests a role for two isoforms of the Ly108 receptor in the pathogenesis of the disease. In this study, we demonstrate that Ly108 is involved in the pathogenesis of lupus-related auto-immunity in mice. More importantly, we identified a third protein isoform, Ly108-H1, which is absent in two lupus-prone congenic animals. Introduction of an Ly108-H1-expressing transgene markedly diminishes T cell-dependent autoimmunity in congenic B6.Sle1b mice. Thus, an immune response-suppressing isoform of Ly108 can regulate the pathogenesis of lupus.

引用

页码：811 / 822

页数：12

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