Adalimumab-induced Interstitial Pneumonia with an Improvement of Pre-existing Rheumatoid Arthritis-associated Lung Involvement

被引：23

作者：

Komiya, Kosaku ^{[1
]}

Ishii, Hiroshi ^{[1
]}

Fujita, Naoko ^{[1
]}

Oka, Hiroaki ^{[1
]}

Iwata, Atsuko ^{[1
]}

Sonoda, Hisako ^{[1
]}

Kadota, Jun-ichi ^{[1
]}

机构：

[1] Oita Univ, Fac Med, Oita, Japan

来源：

INTERNAL MEDICINE | 2011年 / 50卷 / 07期

关键词：

adalimumab; rheumatoid arthritis; drug-induced interstitial pneumonia; tumor necrosis factor-alpha; IDIOPATHIC PULMONARY-FIBROSIS; DISEASE; ETANERCEPT; PATIENT; TRIAL;

D O I：

10.2169/internalmedicine.50.4748

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

A 78-year-old man with an 18-year history of rheumatoid arthritis (RA) was treated with tumor necrosis factor (TNF)-alpha inhibitor adalimumab. Chest computed tomography showed a previously detected consolidation. The patient's arthritic symptoms substantially decreased with the initiation of adalimumab, with a simultaneous improvement of the lung lesion. However, additional interstitial pneumonia was found a month after starting adalimumab. This course suggested that adalimumab might be effective against RA-associated lung disease, but may also have caused drug-induced interstitial pneumonia. This is the first report indicating that TNF-alpha inhibitor shows simultaneously conflicting actions in a patient with RA-related lung disease.

引用

收藏

页码：749 / 751

页数：3

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