学术探索
学术期刊
新闻热点
数据分析
智能评审

Regioselective halogenation of 6-azaindoles: Efficient synthesis of 3-halo-2,3-disubstituted-6-azaindole derivatives

被引：9
作者：
Gallou, F
Reeves, JT
Tan, ZL
Songa, JHJ
Yee, NK
Campbell, S
Jones, PJ
Senanayake, CH
机构：
[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Ridgefield, CT 06877 USA
[2] Boehringer Ingelheim Pharmaceut Inc, Dept Analyt Sci, Ridgefield, CT 06877 USA
来源：
SYNLETT | 2005年 / 15期
关键词：
regioselective halogenation of 6-azaindoles; pyrrolopyridine; copper (II) bromide;
D O I：
10.1055/s-2005-872680
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild and efficient synthesis of 3-halo-2-substituted-6-azaindoles was developed by regioselective halogenation of 6-aza-indole systems. The transformation was achieved with copper(II) bromide in acetonitrile at room temperature.
引用
收藏
页码：2400 / 2402
页数：3
相关论文
共 53 条
  • [1] Alvarez M, 1999, SYNTHESIS-STUTTGART, P615
  • [2] ANDERRSON PL, 1986, Patent No. 4751235
  • [3] PYRROLE CHEMISTRY .4. PREPARATION AND SOME REACTIONS OF BROMINATED PYRROLE DERIVATIVES
    ANDERSON, HJ
    LEE, SF
    [J]. CANADIAN JOURNAL OF CHEMISTRY, 1965, 43 (02): : 409 - &
  • [4] [Anonymous], 1994, CONTEMP ORG SYNTH
  • [5] ANXIOGENIC EFFECTS OF METHYL-BETA-CARBOLINE-3-CARBOXYLATE IN A LIGHT DARK CHOICE SITUATION
    BELZUNG, C
    MISSLIN, R
    VOGEL, E
    DODD, RH
    CHAPOUTHIER, G
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 28 (01) : 29 - 33
  • [6] URINARY AND BRAIN BETA-CARBOLINE-3-CARBOXYLATES AS POTENT INHIBITORS OF BRAIN BENZODIAZEPINE RECEPTORS
    BRAESTRUP, C
    NIELSEN, M
    OLSEN, CE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04): : 2288 - 2292
  • [7] CADGAN JIG, 1965, J CHEM SOC, P4831
  • [8] Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand
    Choi-Sledeski, YM
    Kearney, R
    Poli, G
    Pauls, H
    Gardner, C
    Gong, Y
    Becker, M
    Davis, R
    Spada, A
    Liang, G
    Chu, V
    Brown, K
    Collussi, D
    Leadley, R
    Rebello, S
    Moxey, P
    Morgan, S
    Bentley, R
    Kasiewski, C
    Maignan, S
    Guilloteau, JP
    Mikol, V
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (05) : 681 - 684
  • [9] 2-HALOPYRROLES - SYNTHESIS AND CHEMISTRY
    CORDELL, GA
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1975, 40 (22) : 3161 - 3169
  • [10] THE PICTET-SPENGLER CONDENSATION - A NEW DIRECTION FOR AN OLD REACTION
    COX, ED
    COOK, JM
    [J]. CHEMICAL REVIEWS, 1995, 95 (06) : 1797 - 1842
123456