Body temperature predicts maximum microsatellite length in mammals

被引：7

作者：

Amos, William ^{[1
]}

Clarke, Andrew ^{[2
]}

机构：

[1] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

[2] British Antarctic Survey, NERC, Cambridge CB3 0ET, England

来源：

BIOLOGY LETTERS | 2008年 / 4卷 / 04期

基金：

英国自然环境研究理事会;

关键词：

microsatellite; mutation; genome;

D O I：

10.1098/rsbl.2008.0209

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A long-standing mystery in genome evolution is why short tandem repeats vary so much in length and frequency. Here, we test the hypothesis that body temperature acts to influence the rate and nature of slippage-based mutations. Using the data from both 28 species where genome sequencing is advanced and 76 species from which marker loci have been published, we show that in mammals, maximum repeat number is inversely correlated with body temperature, with warmer-blooded species having shorter 'long' microsatellites. Our results support a model of microsatellite evolution in which maximum length is limited by a temperature-dependent stability threshold.

引用

页码：399 / 401

页数：3

共 19 条

[1] Microsatellites show mutational bias and heterozygote instability [J].