Zinc-catalyzed sulfur alkylation: insights from protein farnesyltransferase

被引：91

作者：

Hightower, KE ^{[1
]}

Fierke, CA ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(99)80030-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zinc metalloenzymes catalyze many important cellular reactions. Recently, the involvement of zinc in the catalysis of alkylation of sulfur groups has gained prominence. Current studies of the zinc metalloenzyme protein farnesyltransferase have shed light on its structure and catalytic mechanism, as well as the general mechanism of zinc-catalyzed sulfur alkylation.

引用

页码：176 / 181

页数：6

共 57 条

[1] CYTIDINE DEAMINASE - THE 2-CENTER-DOT-3-ANGSTROM CRYSTAL-STRUCTURE OF AN ENZYME - TRANSITION-STATE ANALOG COMPLEX [J].

BETTS, L ;

XIANG, SB ;

SHORT, SA ;

WOLFENDEN, R ;

CARTER, CW .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 235 (02) :635-656

[2] SPINACH CARBONIC-ANHYDRASE - INVESTIGATION OF THE ZINC-BINDING LIGANDS BY SITE-DIRECTED MUTAGENESIS, ELEMENTAL ANALYSIS, AND EXAFS [J].

BRACEY, MH ;

CHRISTIANSEN, J ;

TOVAR, P ;

CRAMER, SP ;

BARTLETT, SG .

BIOCHEMISTRY, 1994, 33 (44) :13126-13131

[3] Transition state analogs for protein farnesyltransferase [J].

Cassidy, PB ;

Poulter, CD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (36) :8761-8762

[4] X-RAY-ANALYSIS OF STRUCTURAL-CHANGES INDUCED BY REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE WHEN BOUND TO CYSTEINE-46-CARBOXYMETHYLATED LIVER ALCOHOL-DEHYDROGENASE [J].

CEDERGRENZEPPEZAUER, ES ;

ANDERSSON, I ;

OTTONELLO, S ;

BIGNETTI, E .

BIOCHEMISTRY, 1985, 24 (15) :4000-4010

[5]

CHEN WJ, 1993, J BIOL CHEM, V268, P9675

[6] A MECHANISM FOR POSTTRANSLATIONAL MODIFICATIONS OF PROTEINS BY YEAST PROTEIN FARNESYLTRANSFERASE [J].

DOLENCE, JM ;

POULTER, CD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :5008-5011

[7] Protein farnesyltransferase: Structure and implications for substrate binding [J].

Dunten, P ;

Kammlott, U ;

Crowther, R ;

Weber, D ;

Palermo, R ;

Birktoft, J .

BIOCHEMISTRY, 1998, 37 (22) :7907-7912

[8] Stereochemical analysis of the reaction catalyzed by yeast protein farnesyltransferase [J].

Edelstein, RL ;

Weller, VA ;

Distefano, MD ;

Tung, JS .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (16) :5298-5299

[9] Identification of a cysteine residue essential for activity of protein farnesyltransferase - Cys(299) is exposed only upon removal of zinc from the enzyme [J].

Fu, HW ;

Moomaw, JF ;

Moomaw, CR ;

Casey, PJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (45) :28541-28548

[10] Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase [J].

Fu, HW ;

Beese, LS ;

Casey, PJ .

BIOCHEMISTRY, 1998, 37 (13) :4465-4472

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