Recent Progress in Interfacial Tissue Engineering Approaches for Osteochondral Defects

被引：108

作者：

Castro, Nathan J. ^{[1
,2
]}

Hacking, S. Adam ^{[3
,4
]}

Zhang, Lijie Grace ^{[1
,2
]}

机构：

[1] George Washington Univ, Inst Biomed Engn, Dept Mech & Aerosp Engn, Washington, DC 20052 USA

[2] George Washington Univ, Inst Nanotechnol, Washington, DC 20052 USA

[3] Massachusetts Gen Hosp, Dept Orthopaed, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2012年 / 40卷 / 08期

关键词：

Tissue engineering; Bone; Cartilage; Osteochondral; Interface; Biomimetic; Nanotechnology; MESENCHYMAL STEM-CELLS; SCAFFOLD-FREE CARTILAGE; MUSCLE-DERIVED CELLS; ARTICULAR-CARTILAGE; PROGENITOR CELLS; SUBCHONDRAL BONE; GROWTH-FACTOR; IN-VITRO; NANOCRYSTALLINE HYDROXYAPATITE; OSTEOGENIC DIFFERENTIATION;

D O I：

10.1007/s10439-012-0605-5

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

This review provides a brief synopsis of the anatomy and physiology of the osteochondral interface, scaffold-based and non-scaffold based approaches for engineering both tissues independently as well as recent developments in the manufacture of gradient constructs. Novel manufacturing techniques and nanotechnology will be discussed with potential application in osteochondral interfacial tissue engineering.

引用

页码：1628 / 1640

页数：13

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