Pathological gambling is linked to reduced activation of the mesolimbic reward system

被引：480

作者：

Reuter, J

Raedler, T

Rose, M

Hand, I

Gläscher, J

Büchel, C

机构：

[1] Univ Hamburg, Hosp Eppendorf, Neuroimage Nord, Dept Neurol, D-20246 Hamburg, Germany

[2] Univ Hamburg, Hosp Eppendorf, Neuroimage Nord, Dept Psychiat, D-20246 Hamburg, Germany

[3] Univ Hamburg, Hosp Eppendorf, Dept Psychiat, Behav Therapy Univ, D-20246 Hamburg, Germany

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 02期

关键词：

D O I：

10.1038/nn1378

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.

引用

收藏

页码：147 / 148

页数：2

相关论文

共 15 条

[1] Risky Business: Emotion, Decision-Making, and Addiction [J].

Antoine Bechara .

Journal of Gambling Studies, 2003, 19 (1) :23-51

[2]

Blum K, 1996, AM SCI, V84, P132

[3] Tracking the hemodynamic responses to reward and punishment in the striatum [J].

Delgado, MR ;

Nystrom, LE ;

Fissell, C ;

Noll, DC ;

Fiez, JA .

JOURNAL OF NEUROPHYSIOLOGY, 2000, 84 (06) :3072-3077

[4] Stochastic designs in event-related fMRI [J].

Friston, KJ ;

Zarahn, E ;

Josephs, O ;

Henson, RNA ;

Dale, AM .

NEUROIMAGE, 1999, 10 (05) :607-619

[5] Anticipation of increasing monetary reward selectively recruits nucleus accumbens [J].

Knutson, B ;

Adams, CM ;

Fong, GW ;

Hommer, D .

JOURNAL OF NEUROSCIENCE, 2001, 21 (16) :art. no.-RC159

[6] Temporal prediction errors in a passive learning task activate human striatum [J].

McClure, SM ;

Berns, GS ;

Montague, PR .

NEURON, 2003, 38 (02) :339-346

[7] Temporal difference models and reward-related learning in the human brain [J].

O'Doherty, JP ;

Dayan, P ;

Friston, KJ ;

Critchley, H ;

Dolan, RJ .

NEURON, 2003, 38 (02) :329-337

[8] An fMRI stroop task study of ventromedial prefrontal cortical function in pathological gamblers [J].

Potenza, MN ;

Leung, HC ;

Blumberg, HP ;

Peterson, BS ;

Fulbright, RK ;

Lacadie, CM ;

Skudlarski, P ;

Gore, JC .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (11) :1990-1994

[9] Pathological gambling [J].

Potenza, MN ;

Kosten, TR ;

Rounsaville, BJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (02) :141-144

[10] Drug addiction: bad habits add up [J].

Robbins, TW ;

Everitt, BJ .

NATURE, 1999, 398 (6728) :567-570