The Alpine (29 Ma) stock of Cima di Vila (CdV, Zinsnock), South Tyrol/Alto Adige, Eastern Alps consists of dominant granodiorites with a few tonalites. Late granitic and aplitic dykes cut the pluton, which also contains several microgranular mafic enclaves. Major, trace element and Sr isotopic data reported for samples of various lithologies indicate that mafic, intermediate and acidic magmas in the CdV intrusion are not all strictly comagmatic. Crustal melting of lower continental crust appears to explain better the mineralogical and geochemical characteristics of granodiorites. Mingling between salic and mantle-derived mafic magmas is responsible for the genesis of tonalites, whereas granites and aplites are the products of separation of residual liquid from in situ crystallized granodioritic magma. Studies of mafic enclaves and adjoining host rocks indicate that mafic and acidic magmas interacted extensively during the emplacement dand crystallization of the granodioritic mass. This interaction produced selective enrichments of some elements (Rb, K, Ba) in the mafic magmas at the expense of the nearby acid magmas. Partial crystallization of the mafic magma and equilibration between the residual liquid and the host granodioritic magma produced a depletion of LREE contents in the enclaves. Sr isotopic data indicate that equilibrium between acidic magma and enclaves was not reached, in spite of the large chemical exchanges between mafic blobs and host granodiorites. Late stage fluids from the wall-rocks had an important role in determining Sr isotopic composition of the latest crystallized granitic and aplitic melts.