Chemokine receptor desensitization in tumor-bearing mice

被引：47

作者：

Kurt, RA ^{[1
]}

Baher, A ^{[1
]}

Wisner, KP ^{[1
]}

Tackitt, S ^{[1
]}

Urba, WJ ^{[1
]}

机构：

[1] Oregon Canc Ctr, Providence Portland Med Ctr, Robert W Franz Canc Res Ctr, Earle A Chiles Res Inst,Lab Cellular Immunol, Portland, OR 97213 USA

来源：

CELLULAR IMMUNOLOGY | 2001年 / 207卷 / 02期

关键词：

chemokines; chemokine receptors; receptor desensitization; T cells; tumors;

D O I：

10.1006/cimm.2000.1754

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We found that the murine breast cancer cell line 4T1 constitutively produced several chemokines capable of recruiting T cells. Additionally, supernatants from the tumor cell line mediated chemotaxis of T cells in a pertussis toxin-sensitive manner, indicating that these chemokines were functional. However, we also found an impaired chemotactic ability of splenic T cells in mice bearing these same tumors. The receptors for RANTES, MCP-1, and SLC were desensitized. Thus, the impaired chemotactic ability of T cells in tumor-bearing mice may explain why tumors that secrete chemokines grow progressively in a host. (C) 2001 Academic Press.

引用

页码：81 / 88

页数：8

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