Biosynthesis of porphyrins and related macrocycles .45. Determination by a novel X-ray method of the absolute configuration of the spiro lactam which inhibits uroporphyrinogen III synthase (cosynthetase)

被引：14

作者：

Spivey, AC ^{[1
]}

Capretta, A ^{[1
]}

Frampton, CS ^{[1
]}

Leeper, FJ ^{[1
]}

Battersby, AR ^{[1
]}

机构：

[1] ROCHE PROD LTD,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 17期

关键词：

D O I：

10.1039/p19960002091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach, involving X-ray analysis of a specifically designed racemate, in combination with correlations by circular dichroism, allows the absolute configuration of the spiro lactam 4 to be determined, The outcome is that the enantiomer of this lactam which strongly inhibits uroporphyrinogen III synthase (cosynthetase) has the R-configuration and the implications of this finding are briefly discussed.

引用

页码：2091 / 2102

页数：12

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