Starting the protein synthesis machine: eukaryotic translation initiation

被引：146

作者：

Preiss, T

Hentze, MW

机构：

[1] European Mol Biol Lab, Gene Express Programme, D-69117 Heidelberg, Germany

[2] VCCRI, Mol Genet Program, Sydney, NSW, Australia

来源：

BIOESSAYS | 2003年 / 25卷 / 12期

关键词：

D O I：

10.1002/bies.10362

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The final assembly of the protein synthesis machinery occurs during translation initiation. This delicate process involves both ends of eukaryotic messenger RNAs as well as multiple sequential protein-RNA and protein-protein interactions. As is expected from its critical position in the gene expression pathway between the transcriptome and the proteome, translation initiation is a selective and highly regulated process. This synopsis summarises the current status of the field and identifies intriguing open questions. (C) 2003 Wiley Periodicals, Inc.

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页码：1201 / 1211

页数：11

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