New cytotoxic flavonoids from Cryptocarya infectoria

被引：43

作者：

Dumontet, V

Gaspard, C

Van Hung, N

Fahy, J

Tchertanov, L

Sévenet, T

Guéritte, F

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] NCST, Inst Chim, Hanoi, Vietnam

[3] Ctr Rech Pierre Fabre, Div Chim Med 5, F-81106 Castres, France

来源：

TETRAHEDRON | 2001年 / 57卷 / 29期

关键词：

Cryptocarya infectoria; biflavonoids; cytotoxicity;

D O I：

10.1016/S0040-4020(01)00596-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new dihydrochalcone, two new dihydroflavanones and eight new biflavonoids have been isolated together with cryptocaryone from the cytotoxic methanol extract of Cryptocarya infectoria. The absolute structure of cryptocaryone was established by X-ray analysis of its 8-bromo derivative. The structure of the new compounds were elucidated by spectroscopic means and their absolute stereochemistry was deduced from chemical correlation, circular dichroism data and NOESY experiments. Several compounds displayed significant cytotoxicity and cryptocaryone was shown to possess cytotoxicity towards multi-drug resistant K562-DOX cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6189 / 6196

页数：8

共 13 条

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[2]

EAGLE H, 1955, P SOC EXP BIOL MED, V89, P362

[3] CIRCULAR DICHROISM, OPTICAL ROTATORY DISPERSION AND ABSOLUTE CONFIGURATION OF FLAVANONES, 3-HYDROXYFLAVANONES AND THEIR GLYCOSIDES - DETERMINATION OF AGLYCONE CHIRALITY IN FLAVANONE GLYCOSIDES [J].