How are the cellular functions of myosin V1 regulated within the cell?

被引：71

作者：

Buss, Folma ^{[2
]}

Kendrick-Jones, John ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[2] Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 2XY, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 369卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

motor proteins; myosin VI; actin; cytoskeleton; PtdIns(4,5)P-2; membrane trafficking; myosin phosphorylation; optineurin; Dab2; GIPC;

D O I：

10.1016/j.bbrc.2007.11.150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review, dedicated to the memory of Professor Setsuro Ebashi, focuses on our current work investigating the cellular functions and regulation of the unique unconventional motor, myosin VI. This myosin, unlike all the other myosins so far studied, moves towards the minus end of actin filaments and has been implicated in a wide range of cellular processes such as endocytosis, exocytosis, cell migration, cell division and cytokinesis. Myosin VI's involvement in these cellular pathways is mediated by its interaction with specific adaptor proteins and is regulated by multiple regulatory signals and modifications such as calcium ions, PtdIns(4,5)P-2 (PIP2) and phosphorylation. Understanding the functions of myosin VI within the cell and how it is regulated is now of utmost importance given the recent observations that it is associated with a number of human disorders such as deafness and cancers. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：165 / 175

页数：11

共 106 条

[1] REGULATION AND KINETICS OF THE ACTIN-MYOSIN-ATP INTERACTION [J].

ADELSTEIN, RS ;

EISENBERG, E .

ANNUAL REVIEW OF BIOCHEMISTRY, 1980, 49 :921-956

[2] PHOSPHORYLATION OF PLATELET MYOSIN INCREASES ACTIN-ACTIVATED MYOSIN ATPASE ACTIVITY [J].

ADELSTEIN, RS ;

CONTI, MA .

NATURE, 1975, 256 (5518) :597-598

[3] The mechanism of myosin VI translocation an its load-induced anchoring [J].

Altman, D ;

Sweeney, HL ;

Spudich, JA .

CELL, 2004, 116 (05) :737-749

[4] Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells [J].

Ang, AL ;

Taguchi, T ;

Francis, S ;

Fölsch, H ;

Murrells, LJ ;

Pypaert, M ;

Warren, G ;

Mellman, I .

JOURNAL OF CELL BIOLOGY, 2004, 167 (03) :531-543

[5] Myo6 facilitates the translocation of endocytic vesicles from cell peripheries [J].

Aschenbrenner, L ;

Lee, T ;

Hasson, T .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (07) :2728-2743

[6] Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cells [J].

Au, Josephine Sui-Yan ;

Puri, Claudia ;

Ihrke, Gudrun ;

Kendrick-Jones, John ;

Buss, Folma .

JOURNAL OF CELL BIOLOGY, 2007, 177 (01) :103-114

[7] The unique insert in myosin VI is a structural calcium-calmodulin binding site [J].

Bahloul, A ;

Chevreux, G ;

Wells, AL ;

Martin, D ;

Nolt, J ;

Yang, ZH ;

Chen, LQ ;

Potiert, N ;

Van Dorsselaer, A ;

Rosenfeld, S ;

Houdusse, A ;

Sweeney, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (14) :4787-4792

[8] TEDS RULE - A MOLECULAR RATIONALE FOR DIFFERENTIAL REGULATION OF MYOSINS BY PHOSPHORYLATION OF THE HEAVY-CHAIN HEAD [J].

BEMENT, WM ;

MOOSEKER, MS .

CELL MOTILITY AND THE CYTOSKELETON, 1995, 31 (02) :87-92

[9] A millennial myosin census [J].

Berg, JS ;

Powell, BC ;

Cheney, RE .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (04) :780-794

[10] Expression of myosin VI within the early endocytic pathway in adult and developing proximal tubules [J].

Biemesderfer, D ;

Mentone, SA ;

Mooseker, M ;

Hasson, T .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2002, 282 (05) :F785-F794

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