Antimicrobial activities and postantibiotic effects of clarithromycin, 14-hydroxy-clarithromycin, and azithromycin in epithelial cell lining fluid against clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae

被引:15
作者
Bergman, KL
Olsen, KM
Peddicord, TE
Fey, PD
Rupp, ME
机构
[1] Univ Nebraska, Med Ctr, Dept Pharm Practice, Omaha, NE 68198 USA
[2] Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE 68198 USA
关键词
D O I
10.1128/AAC.43.5.1291
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin against Streptococcus pneumoniae. Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin against Haemophilus influenzae. Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.
引用
收藏
页码:1291 / 1293
页数:3
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