Positron emission tomography for quantitative determination of glucose metabolism in normal and ischemic brains in rats: An insoluble problem by the Harderian glands

被引：39

作者：

Kuge, Y ^{[1
]}

Minematsu, K ^{[1
]}

Hasegawa, Y ^{[1
]}

Yamaguchi, T ^{[1
]}

Mori, H ^{[1
]}

Matsuura, H ^{[1
]}

Hashimoto, N ^{[1
]}

Miyake, Y ^{[1
]}

机构：

[1] NATL CARDIOVASC CTR,RES INST,CEREBROVASC LAB,SUITA,OSAKA 565,JAPAN

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1997年 / 17卷 / 01期

关键词：

rat; positron emission tomography (PET); cerebral metabolic rate of glucose (CMR(glc)); focal brain ischemia; Harderian gland;

D O I：

10.1097/00004647-199701000-00015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To examine the reliability of quantitative positron emission tomography studies in the rat (Rat-PET), we assessed the influence of radioactivity accumulated in the Harderian glands on PET CMR(glc) determination. We measured CMR(glc) by PET and ex vivo dissection methods by using 2-[F-18]fluoro-2-deoxy-D-glucose in rats with and without focal brain ischemia. The CMR(glc) values obtained by PET, after correcting with recovery coefficients, were higher than those measured by the ex vivo method at rostral slices, and reduction of the CMR(glc) in the ischemic brain was not demonstrated by PET in the frontal cortex, The radioactivity accumulated in the Harderian glands prevents the quantitative determination of CMR(glc) using Rat-PET.

引用

页码：116 / 120

页数：5

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