Adrenomedullin regulation by thyroid hormone in the rat

被引：11

作者：

Murakami, Y

Hattori, Y ^{[1
]}

Taniyama, M

Kitamura, K

Kasai, K

机构：

[1] Dokkyo Univ, Sch Med, Dept Endocrinol, Mibu, Tochigi 3210293, Japan

[2] Showa Univ, Dept Internal Med 3, Tokyo, Japan

[3] Miyazaki Med Coll, Dept Internal Med 1, Miyazaki 88916, Japan

来源：

LIFE SCIENCES | 1998年 / 63卷 / 24期

关键词：

adrenomedullin; thyroid hormone; rat; promoter;

D O I：

10.1016/S0024-3205(98)00503-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To investigate the effect of thyroid hormone on adrenomedullin (AM) changes during hyper- and hypothyroid states, we evaluated plasma AM concentrations and AM mRNA levels in lung tissue from hyper- and hypothyroid rats. AM peptide concentrations were significantly higher in plasma from hyperthyroid rats and lower in plasma from hypothyroid rats compared with control rats. AM mRNA transcripts were significantly increased in lung tissue from hyperthyroid rats and significantly decreased in lung tissue from hypothyroid rats compared with normal rats. These changes are paralleled alterations in AM production in cultured rat vascular smooth muscle cells, in which AM is regulated at the transcriptional level by thyroid hormone. Thus, thyroid hormone positively regulates AM production in vivo. (C) 1998 Elsevier Science Inc.

引用

页码：PL337 / PL342

页数：6

共 17 条

[1]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[2] SPECIFIC RECEPTORS FOR ADRENOMEDULLIN IN CULTURED RAT VASCULAR SMOOTH-MUSCLE CELLS [J].