Genome-Wide Association Study of the Child Behavior Checklist Dysregulation Profile

被引：59

作者：

Mick, Eric ^{[1
]}

McGough, James ^{[2
,3
]}

Loo, Sandra ^{[3
,4
]}

Doyle, Alysa E. ^{[5
,6
]}

Wozniak, Janet ^{[5
,6
]}

Wilens, Timothy E. ^{[5
,6
]}

Smalley, Susan ^{[3
,4
]}

McCracken, James ^{[2
,3
]}

Biederman, Joseph ^{[5
,6
]}

Faraone, Stephen V. ^{[7
]}

机构：

[1] Univ Massachusetts, Sch Med, Worcester, MA 01655 USA

[2] Univ Calif Los Angeles, Div Child & Adolescent Psychiat, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA

[3] David Geffen Sch Med, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90024 USA

[5] Massachusetts Gen Hosp, Boston, MA 02114 USA

[6] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

[7] SUNY Upstate Med Univ, Syracuse, NY USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY | 2011年 / 50卷 / 08期

基金：

美国国家卫生研究院;

关键词：

ADHD; emotional dysregulation; CBCL; GWAS; DEFICIT HYPERACTIVITY DISORDER; PEDIATRIC BIPOLAR DISORDER; AUTISM SPECTRUM DISORDERS; FAMILY-BASED ASSOCIATION; QUANTITATIVE TRAITS; SIGNALING PATHWAYS; GROWTH CONES; HUMAN BRAIN; LINKAGE; PHENOTYPE;

D O I：

10.1016/j.jaac.2011.05.001

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Objective: : A potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales (CBCL-DP). The CBCL-DP indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. We have conducted a genome-wide association study of the CBCL-DP in children with attention-deficit/hyperactivity disorder (ADHD). Method: Families were ascertained at Massachusetts General Hospital and University of California, Los Angeles. Genotyping was conducted with the Illumina Human1M or Human1M-Duo Bead Chip platforms. Genome-wide association analyses were conducted with the MQFAM multivariate extension of PLINK. Results: CBCL data were available for 341 ADHD offspring from 339 ADHD affected trio families from the UCLA (N = 128) and the MGH (N = 213) sites. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1. Conclusions: We found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP. J. Am. Acad. Child Adolesc. Psychiatry, 2011;50(8): 807-817.

引用

页码：807 / 817

页数：11

共 62 条

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