Olanzapine treatment after clozapine-induced granulocytopenia in 3 patients

被引：16

作者：

Swartz, JR ^{[1
]}

Ananth, J ^{[1
]}

Smith, MW ^{[1
]}

Burgoyne, KS ^{[1
]}

Gadasally, R ^{[1
]}

Arai, Y ^{[1
]}

机构：

[1] Harbor UCLA Med Ctr, Dept Psychiat, Torrance, CA 90509 USA

来源：

JOURNAL OF CLINICAL PSYCHIATRY | 1999年 / 60卷 / 02期

关键词：

D O I：

10.4088/JCP.v60n0209

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem. Case reports: We report 3 patients with chronic schizophrenia who had previously stopped clozapine due to hematologic side effects. The patients evidenced improvement with olanzapine that equated to 16- to 31-point decreases in rating scale scores during I-year follow-up without any hematologic abnormalities. Conclusion: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.

引用

页码：119 / 121

页数：3

共 13 条

[1] CLOZAPINE-INDUCED AGRANULOCYTOSIS - SITUATION REPORT UP TO AUGUST 1976 [J].

ANDERMAN, B ;

GRIFFITH, RW .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1977, 11 (03) :199-201

[2]

BURGOYNE K, 1996, EUR NEUROPSYCHOPHA S, V6, P148

[3]

FULLER RW, 1992, RES COMMUN CHEM PATH, V77, P87

[4]

KANE J, 1988, ARCH GEN PSYCHIAT, V45, P789

[5] THE POSITIVE AND NEGATIVE SYNDROME SCALE (PANSS) FOR SCHIZOPHRENIA [J].

KAY, SR ;

FISZBEIN, A ;

OPLER, LA .

SCHIZOPHRENIA BULLETIN, 1987, 13 (02) :261-276

[6] LEPONEX - ASSOCIATED GRANULOCYTOPENIA - A REVIEW OF THE SITUATION [J].

KRUPP, P ;

BARNES, P .

PSYCHOPHARMACOLOGY, 1989, 99 :S118-S121

[7]

Lieberman J A, 1992, Drug Saf, V7 Suppl 1, P1

[8]

LIEBERMAN JA, 1988, J CLIN PSYCHIAT, V49, P271

[9]

MA J, 1994, J CLIN PSYCHIAT, V55, P137

[10]

OVERALL JE, 1962, PSYCHOL REP, V10, P799

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