The cytoprotective Nrf2 transcription factor controls insulin receptor signaling in the regenerating liver

被引：44

作者：

Beyer, Tobias A. ^{[1
]}

Werner, Sabine ^{[1
]}

机构：

[1] Univ Zurich, Inst Cell Biol, Dept Biol, CH-8093 Zurich, Switzerland

来源：

CELL CYCLE | 2008年 / 7卷 / 07期

关键词：

Nrf2; insulin; IGF-1; liver regeneration; oxidative stress; PI3K; ROS;

D O I：

10.4161/cc.7.7.5617

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Nrf2 transcription factor is a crucial regulator of the cellular redox homeostasis through its capacity to induce the expression of enzymes, which detoxify reactive oxygen species, and of other antioxidant proteins. Therefore, it plays an important role in the protection from carcinogenesis induced by various insults. In addition, recent results identified a novel role of Nrf2 in tissue repair. In the liver, regeneration after partial hepatectomy was strongly delayed in the absence of Nrf2. This defect was shown to result from transient resistance to insulin and insulin-like growth factor 1 that was caused by chronic oxidative stress in hepatocytes. These results demonstrate a link between Nrf2 deficiency, oxidative stress and insulin resistance, and suggest that activation of this transcription factor could be a novel strategy to improve liver regeneration in patients with acute or chronic liver injury. In addition, it may help to alleviate oxidative stress-induced insulin resistance in the liver and potentially also in other organs.

引用

页码：874 / 878

页数：5

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