Methicillin-susceptible, non-multiresistant methicillin-resistant and multiresistant methicillin-resistant Staphylococcus aureus infections:: a clinical, epidemiological and microbiological comparative study

被引:59
作者
Munckhof, W. J. [1 ]
Nimmo, G. R. [2 ]
Carney, J. [1 ]
Schooneveldt, J. M. [2 ]
Huygens, F. [3 ]
Inman-Bamber, J. [3 ]
Tong, E. [1 ]
Morton, A. [1 ]
Giffard, P. [3 ]
机构
[1] Princess Alexandra Hosp, Infect Management Serv, Brisbane, Qld 4102, Australia
[2] Princess Alexandra Hosp, QHPS, Dept Microbiol, Brisbane, Qld 4102, Australia
[3] Queensland Univ Technol, Cooperat Res Ctr Diagnost, Brisbane, Qld 4000, Australia
关键词
D O I
10.1007/s10096-007-0449-3
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Non-multiresistant methicillin-resistant Staphylococcus aureus (nmMRSA) infections are emerging worldwide and are often community-associated. This prospective case-cohort study compares features of 96 nmMRSA clinical isolates with 96 matched multiresistant MRSA (mMRSA) and 192 matched methicillin-susceptible S. aureus (MSSA) clinical isolates. Seventy-four percent of nmMRSA infections were healthcare-associated. nmMRSA infections were much more likely to involve skin and soft tissue (skin and soft tissue infections; SSTIs) and were much less likely to be treated appropriately with antibiotics than MSSA or mMRSA infections. Panton-Valentine leukocidin (PVL) genes were detected in 55% of nmMRSA, 16% of MSSA and 2% of mMRSA isolates. Independent of the methicillin-resistance phenotype, 59% of PVL-positive SSTIs presented as furunculosis compared to only 10% of PVL-negative SSTIs. Patients with PVL-positive infections were much younger than patients with PVL-negative infections. The proportion of PVL-positive infections peaked in the 10-29 years old age group, followed by a linear decline.
引用
收藏
页码:355 / 364
页数:10
相关论文
共 46 条
[1]  
[Anonymous], 2006, R LANG ENV STAT COMP
[2]  
[Anonymous], 1999, MMWR-MORBID MORTAL W, V48, P707
[3]   Five cases of bacterial endocarditis after furunculosis and the ongoing saga of community-acquired methicillin-resistant Staphylococcus aureus infections [J].
Bahrain, Michelle ;
Vasiliades, Minas ;
Wolff, Marcos ;
Younus, Faheem .
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2006, 38 (08) :702-707
[4]   Panton-Valentine leukocidin genes are associated with enhanced inflammatory response and local disease in acute hematogenous Staphylococcus aureus osteomyelitis in children [J].
Bocchini, CE ;
Hulten, KG ;
Mason, EO ;
Gonzalez, BE ;
Hammerman, WA ;
Kaplan, SL .
PEDIATRICS, 2006, 117 (02) :433-440
[5]   Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection [J].
Burlak, Christopher ;
Hammer, Carl H. ;
Robinson, Mary-Ann ;
Whitney, Adeline R. ;
McGavin, Martin J. ;
Kreiswirth, Barry N. ;
DeLeo, Frank R. .
CELLULAR MICROBIOLOGY, 2007, 9 (05) :1172-1190
[6]  
*CDCP, 2003, MMWR-MORBID MORTAL W, V52, P793
[7]   Community-acquired meticillin-resistant Staphylococcus aureus in Australia [J].
Collignon, P ;
Gosbell, I ;
Vickery, A ;
Nimmo, G ;
Stylianopoulos, T ;
Gottlieb, T .
LANCET, 1998, 352 (9122) :145-146
[8]  
Coombs GW, 2006, EMERG INFECT DIS, V12, P241
[9]   Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus [J].
Enright, MC ;
Day, NPJ ;
Davies, CE ;
Peacock, SJ ;
Spratt, BG .
JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (03) :1008-1015
[10]   Methicillin-resistant staphylococcus aureus disease in three communities [J].
Fridkin, SK ;
Hageman, JC ;
Morrison, M ;
Sanza, LT ;
Como-Sabetti, K ;
Jernigan, JA ;
Harriman, K ;
Harrison, LH ;
Lynfield, R ;
Farley, MM .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (14) :1436-1444