Linear differentiation of cytotoxic effectors into memory T lymphocytes

被引：311

作者：

Opferman, JT

Ober, BT

Ashton-Rickardt, PG ^{[1
]}

机构：

[1] Univ Chicago, Gwen Knapp Ctr Lupus & Immunol Res, Comm Immunol, Chicago, IL 60637 USA

[2] Univ Chicago, Gwen Knapp Ctr Lupus & Immunol Res, Dept Pathol, Chicago, IL 60637 USA

[3] Univ Chicago, Gwen Knapp Ctr Lupus & Immunol Res, Comm Dev Biol, Chicago, IL 60637 USA

来源：

SCIENCE | 1999年 / 283卷 / 5408期

关键词：

D O I：

10.1126/science.283.5408.1745

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A central question in immunology is the origin of Long-Lived T cell memory that confers protection against recurrent infection. The differentiation of nai:ve T cell receptor transgenic CD8(+) cells into effector cytotoxic T Lymphocytes (CTLs) and memory CD8(+) cells was studied. Memory CD8(+) cells that were generated after strong antigenic stimulation were the progeny of cytotoxic effecters and retained antigen-specific cytolytic activity 10 weeks after adoptive transfer to antigen-free recipient mice. Thus, potential vaccines based on CTL memory will require the differentiation of naiive cells into post-effector memory T cells.

引用

页码：1745 / 1748

页数：4

共 28 条

[1] Immunological memory and protective immunity: Understanding their relation [J].