The Drosophila lymph gland as a developmental model of hematopoiesis

被引:296
作者
Jung, SH
Evans, CJ
Uemura, C
Banerjee, U [1 ]
机构
[1] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA
来源
DEVELOPMENT | 2005年 / 132卷 / 11期
关键词
Drosophila; hematopoiesis; blood; hemocyte; lymph gland;
D O I
10.1242/dev.01837
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Drosophila hematopoiesis occurs in a specialized organ called the lymph gland. In this systematic analysis of lymph gland structure and gene expression, we define the developmental steps in the maturation of blood cells (hemocytes) from their precursors. In particular, distinct zones of hemocyte maturation, signaling and proliferation in the lymph gland during hematopoietic progression are described. Different stages of hemocyte development have been classified according to marker expression and placed within developmental niches: a medullary zone for quiescent prohemocytes, a cortical zone for maturing hemocytes and a zone called the posterior signaling center for specialized signaling hemocytes. This establishes a framework for the identification of Drosophila blood cells, at various stages of maturation, and provides a genetic basis for spatial and temporal events that govern hemocyte development. The cellular events identified in this analysis further establish Drosophila as a model system for hematopoiesis.
引用
收藏
页码:2521 / 2533
页数:13
相关论文
共 67 条
[1]   Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury [J].
Agaisse, H ;
Petersen, UM ;
Boutros, M ;
Mathey-Prevot, B ;
Perrimon, N .
DEVELOPMENTAL CELL, 2003, 5 (03) :441-450
[2]   gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila [J].
Alfonso, TB ;
Jones, BW .
DEVELOPMENTAL BIOLOGY, 2002, 248 (02) :369-383
[3]  
Asha H, 2003, GENETICS, V163, P203
[4]   Dissection of cis-regulatory elements of the Drosophila gene Serrate [J].
Bachmann, A ;
Knust, E .
DEVELOPMENT GENES AND EVOLUTION, 1998, 208 (06) :346-351
[5]  
Bernardoni R, 1997, DEV BIOL, V191, P118
[6]   The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow [J].
Bjerregaard, MD ;
Jurlander, J ;
Klausen, P ;
Borregaard, N ;
Cowland, JB .
BLOOD, 2003, 101 (11) :4322-4332
[7]  
BLOCHLINGER K, 1993, DEVELOPMENT, V117, P441
[8]   A P-insertion screen identifying novel X-linked essential genes in Drosophila [J].
Bourbon, HM ;
Gonzy-Treboul, G ;
Peronnet, F ;
Alin, MF ;
Ardourel, C ;
Benassayag, C ;
Cribbs, D ;
Deutsch, J ;
Ferrer, P ;
Haenlin, M ;
Lepesant, JA ;
Noselli, S ;
Vincent, A .
MECHANISMS OF DEVELOPMENT, 2002, 110 (1-2) :71-83
[9]  
Braun A, 1997, GENETICS, V147, P623
[10]   Drosophila:: The genetics of innate immune recognition and response [J].
Brennan, CA ;
Anderson, KV .
ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 :457-483