Lonicerae Japonicae Flos and Lonicerae Flos: A Systematic Pharmacology Review

被引：53

作者：

Li, Yujie ^{[1
]}

Cai, Weiyan ^{[1
]}

Weng, Xiaogang ^{[1
]}

Li, Qi ^{[1
]}

Wang, Yajie ^{[1
]}

Chen, Ying ^{[1
]}

Zhang, Wei ^{[1
]}

Yang, Qing ^{[1
]}

Guo, Yan ^{[1
]}

Zhu, Xiaoxin ^{[1
]}

Wang, Hainan ^{[2
]}

机构：

[1] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

[2] China Food & Drug Adm, Dept Drug & Cosmet Registrat, Beijing 100053, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2015年 / 2015卷

基金：

中国国家自然科学基金;

关键词：

MACRANTHOIDES-HAND; MAZZ; FLOWER BUDS; THUNB; INHIBITION; ACTIVATION; NEUROTOXICITY; SECRETION; APOPTOSIS; PI3K/AKT;

D O I：

10.1155/2015/905063

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Lonicerae japonicae flos, a widely used traditional Chinese medicine (TCM), has been used for several thousand years in China. Chinese Pharmacopeia once included Lonicerae japonicae flos of Caprifoliaceae family and plants of the same species named Lonicerae flos in general in the same group. Chinese Pharmacopeia (2005 Edition) lists Lonicerae japonicae flos and Lonicerae flos under different categories, although they have the similar history of efficacy. In this study, we research ancient books of TCM, 4 main databases of Chinese academic journals, and MEDLINE/PubMed to verify the origins and effects of Lonicerae japonicae flos and Lonicerae flos in traditional medicine and systematically summarized the research data in light of modern pharmacology and toxicology. Our results show that Lonicerae japonicae flos and Lonicerae flos are similar pharmacologically, but they also differ significantly in certain aspects. A comprehensive systematic review and a standard comparative pharmacological study of Lonicerae japonicae flos and Lonicerae flos as well as other species of Lonicerae flos support their clinical safety and application. Our study provides evidence supporting separate listing of Lonicerae japonicae flos and Lonicerae flos in Chinese Pharmacopeia as well as references for revision of relevant pharmacopeial records dealing with traditional efficacy of Lonicerae japonicae flos and Lonicerae flos.

引用

页数：16

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