Cardiac energy metabolism: Models of cellular respiration

被引：61

作者：

Jafri, MS ^{[1
]}

Dudycha, SJ

O'Rourke, B

机构：

[1] Univ Texas, Dept Math Sci, Richardson, TX 75083 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Inst Mol Cardiobiol, Baltimore, MD 21205 USA

来源：

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING | 2001年 / 3卷

关键词：

glycolysis; oxidative phosphorylation; tricarboxylic acid cycle; electron transport; computer model;

D O I：

10.1146/annurev.bioeng.3.1.57

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The heart requires a large amount of energy to sustain both ionic homeostasis and contraction. Under normal conditions, adenosine triphosphate (ATP) production meets this demand. Hence, there is a complex regulatory system that adjusts energy production to meet this demand. However, the mechanisms for this control are a topic of active debate. Energy metabolism can be divided into three main stages: substrate delivery to the tricarboxylic acid (TCA) cycle, the TCA cycle, and oxidative phosphorylation. Each of these processes has multiple control points and exerts control over the other stages. This review discusses the basic stages of energy metabolism, mechanisms of control, and the mathematical and computational models that have been used to study these mechanisms.

引用

页码：57 / 81

页数：25

共 113 条

[1] COMPUTER-SIMULATION OF METABOLISM IN PYRUVATE-PERFUSED RAT-HEART .4. MODEL BEHAVIOR [J].