Decapitation of a 5' capped RNA by an antisense copper complex conjugate

被引：15

作者：

Baker, BF

Ramasamy, K

Kiely, J

机构：

[1] Isis Pharmaceuticals, Inc., Carlsbad, CA 92008

[2] ICN, Costa Mesa, CA 92626

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 14期

关键词：

D O I：

10.1016/0960-894X(96)00295-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This report presents the synthesis and 5' cap reactivity of an antisense oligodeoxynucleotide equipped with two equivalents of an analog of N-(2-mercaptopropionyl)glycine (MPG). MPG is a peptide derivative which coordinates to copper(II) in solution as a monomeric species via the thiol, amide, and carboxylate groups. Decapitation of a complementary 5' capped RNA was observed for the oligonucleotide-ligand conjugate coordinated to copper. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1647 / 1652

页数：6

共 30 条

[1]

[Anonymous], ANTISENSE RES APPL

[2] DECAPITATION OF A 5'-CAPPED OLIGORIBONUCLEOTIDE BY O-PHENANTHROLINE-CU(II) [J].