Nanosilver based anionic linear globular dendrimer with a special significant antiretroviral activity

被引：28

作者：

Ardestani, Mehdi Shafiee ^{[1
]}

Fordoei, Alireza Salehi ^{[2
,3
,4
]}

Abdoli, Asghar ^{[2
,3
]}

Cohan, Reza Ahangari ^{[5
]}

Bahramali, Golnaz ^{[2
,3
]}

Sadat, Seyed Mehdi ^{[2
,3
]}

Siadat, Seyed Davar ^{[6
]}

Moloudian, Hamid ^{[7
]}

Koopaei, Nasser Nassiri ^{[8
]}

Bolhasani, Azam ^{[2
,3
]}

Rahimi, Pooneh ^{[2
,3
]}

Hekmat, Soheila ^{[2
,3
]}

Davari, Mehdi ^{[2
,3
]}

Aghasadeghi, Mohammad Reza ^{[2
,3
]}

机构：

[1] Univ Tehran Med Sci, Dept Radiopharmacy, Fac Pharm, Tehran, Iran

[2] Pasteur Inst Iran, Dept Hepatitis, Tehran 13164, Iran

[3] Pasteur Inst Iran, AIDS, Tehran 13164, Iran

[4] Islamic Azad Univ, Dept Biol, Coll Basic Sci, Tehran Sci & Res Branch, Tehran, Iran

[5] Pasteur Inst Iran, Virol Res Grp, Dept Rabies, Tehran 13164, Iran

[6] Pasteur Inst Iran, Dept Bacteriol, Tehran 13164, Iran

[7] Univ Tehran Med Sci, Fac Pharm, Pharmaceut Qual Assurance Res Ctr, Tehran, Iran

[8] Univ Tehran Med Sci, Dept Pharmaceut Biotechnol, Fac Pharm, Tehran, Iran

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2015年 / 26卷 / 05期

关键词：

DRUG-DELIVERY SYSTEMS; SILVER NANOPARTICLES; HIV-1; INFECTION; HYDROXYUREA; INACTIVATION; SUPPRESSION; INHIBITION; DIDANOSINE; POLYMERS; ACID;

D O I：

10.1007/s10856-015-5510-7

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

HIV is commonly caused to a very complicated disease which has not any recognized vaccine, so designing and development of novel antiretroviral agents with specific application of nanomedicine is a globally interested research subject worldwide. In the current study, a novel structure of silver complexes with anionic linear globular dendrimer was synthesized, characterized and then assessed against HIV replication pathway in vitro as well. The results showed a very good yield of synthesis (up to 70 %) for the nano-complex as well as a very potent significant (P < 0.05) antiretroviral activity with non-severe toxic effects in comparison with the Nevirapine as standard drug in positive control group. According to the present data, silver anionic linear globular dendrimers complex may have a promising future to inhibit replication of HIV viruse in clinical practice.

引用

页数：8

共 47 条

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Anionic linear-globular dendrimers: biocompatible hybrid materials with potential uses in nanomedicine [J].