Electrocatalytic oxidation and simultaneous determination of uric acid and ascorbic acid on the gold nanoparticles-modified glassy carbon electrode

被引：155

作者：

Hu, Guangzhi ^{[1
,2
]}

Ma, Yonggen ^{[1
,2
]}

Guo, Yong ^{[1
]}

Shao, Shijun ^{[1
]}

机构：

[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

ELECTROCHIMICA ACTA | 2008年 / 53卷 / 22期

关键词：

gold nanoparticles self-assembled electrode; uric acid; ascorbic acid; simultaneous determination; differential pulse voltammetry;

D O I：

10.1016/j.electacta.2008.04.054

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

A new gold nanoparticles-modified electrode (GNP/LC/GCE) was fabricated by self-assembling gold nanoparticles to the surface of the L-cysteine-modified glassy carbon electrode. The modified electrode showed an excellent character for electrocatalytic oxidization of uric acid (UA) and ascorbic acid (AA) with a 0.306 V separation of both peaks, while the bare GC electrode only gave an overlapped and broad oxidation peak. The anodic currents of UA and AA on the modified electrode were 6- and 2.5-fold to that of the bare GCE, respectively. Using differential pulse voltammetry (DPV), a highly selective and simultaneous determination of UA and AA has been explored at the modified electrode. DPV peak currents of UA and AA increased linearly with their concentration at the range of 6.0 x 10(-7) to 8.5 x 10(-4) mol L-1 and 8.0 x 10(-6) to 5.5 x 10(-3) mol L-1, respectively. The proposed method was applied for the detection of UA and AA in human urine with satisfactory result. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6610 / 6615

页数：6

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