Neural correlates of genetically abnormal social cognition in Williams syndrome

被引：266

作者：

Meyer-Lindenberg, A ^{[1
]}

Hariri, AR

Munoz, KE

Mervis, CB

Mattay, VS

Morris, CA

Berman, KF

机构：

[1] NIMH, Sect Integrat Neuroimaging, NIH, US Dept HHS, Bethesda, MD 20892 USA

[2] NIMH, Neuroimaging Core Facil, NIH, US Dept HHS, Bethesda, MD 20892 USA

[3] NIMH, Clin Brain Disorders Branch, Genes Cognit & Psychosis Program, NIH,US Dept HHS, Bethesda, MD 20892 USA

[4] Univ Louisville, Dept Psychol & Brain Sci, Neurodev Sci Lab, Louisville, KY 40292 USA

[5] Univ Nevada, Sch Med, Dept Pediat, Las Vegas, NV 89102 USA

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 08期

关键词：

D O I：

10.1038/nn1494

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety. Using functional neuroimaging, we found reduced amygdala activation in individuals with WBS for threatening faces but increased activation for threatening scenes, relative to matched normal controls. Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior.

引用

页码：991 / 993

页数：3

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