Disposable integrated cuvette test for quantitative determination of vitamin C in pharmaceutical products

被引：29

作者：

Koncki, R ^{[1
]}

Lenarczuk, T ^{[1
]}

Glab, S ^{[1
]}

机构：

[1] Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland

来源：

ANALYTICA CHIMICA ACTA | 1999年 / 379卷 / 1-2期

关键词：

spectrophotometry; ascorbic acid; pharmaceutical analysis; Prussian blue;

D O I：

10.1016/S0003-2670(98)00653-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Disposable, plastic cuvettes with integrated sensor layer made of Prussian blue were used for spectrophotometric determination of vitamin C in pharmaceutical products. Ascorbates cause discolouration of the layer due to its reduction to the Prussian white. The decrease of absorbance of the film measured at 720 nm is used as the analytical signal. No additional reagents are required. Under optimized conditions the test allows fast (up to 5 min) determination of ascorbate in the 0.1-10 mM range of concentration. The test is selective for vitamin C. The results of pharmaceuticals analyses are comparable to those obtained using reference pharmacopeal method. The test enables analysis of turbid samples. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：69 / 74

页数：6

共 13 条

[1] SPECTROPHOTOMETRIC AND TITRIMETRIC METHODS FOR THE DETERMINATION OF VITAMIN-C BASED ON ITS REACTION WITH THE FERRICINIUM CATION [J].