Exploring the Role of Soluble Factors Associated with Immune Regulatory Properties of Mesenchymal Stem Cells

被引：120

作者：

Bassi, Enio Jose ^{[1
]}

de Almeida, Danilo Candido ^{[2
]}

Mendes Moraes-Vieira, Pedro Manoel ^{[1
]}

Saraiva Camara, Niels Olsen ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Lab Transplantat Immunobiol, BR-05508000 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Div Nephrol, Dept Med, BR-04039000 Sao Paulo, Brazil

来源：

STEM CELL REVIEWS AND REPORTS | 2012年 / 8卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Mesenchymal stem cells; Immune regulation; Immune system; Soluble factors; Immunotherapy; Inflammation; LEUKEMIA INHIBITORY FACTOR; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; THERAPY POSITION STATEMENT; T-LYMPHOCYTE PROLIFERATION; ANTIGEN-PRESENTING CELLS; GROWTH-FACTOR-BETA; STROMAL CELLS; NITRIC-OXIDE; DENDRITIC CELLS; UMBILICAL-CORD;

D O I：

10.1007/s12015-011-9311-1

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Mesenchymal stem cells (MSCs) are characterized as multipotent stromal cells with the capacity for both self-renewal and differentiation into mesodermal cell lineages. MSCs also have a fibroblast-like phenotype and can be isolated from several tissues. In recent years, researchers have found that MSCs secrete several soluble factors that exert immunosuppressive effects by modulating both innate (macrophages, dendritic and NK cells) and adaptive (B cells and CD4+ and CD8+ T cells) immune responses. This review summarizes the principal trophic factors that are related to immune regulation and secreted by MSCs under both autoimmune and inflammatory conditions. The understanding of mechanisms that regulate immunity in MSCs field is important for their future use as a novel cellular-based immunotherapy with clinical applications in several diseases.

引用

页码：329 / 342

页数：14

共 114 条

[1]

Human mesenchymal stem cells modulate allogeneic immune cell responses [J].