The functional role of long non-coding RNA in human carcinomas

被引：1443

作者：

Gibb, Ewan A. ^{[1
]}

Brown, Carolyn J. ^{[1
,2
]}

Lam, Wan L. ^{[1
,3
]}

机构：

[1] British Columbia Canc Agcy, Res Ctr, Vancouver, BC V5Z 4E6, Canada

[2] Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada

[3] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada

来源：

MOLECULAR CANCER | 2011年 / 10卷

关键词：

PROSTATE-SPECIFIC GENE; TUMOR-SUPPRESSOR GENE; EXPRESSING DIPHTHERIA-TOXIN; X-CHROMOSOME INACTIVATION; HUMAN MICRORNA GENES; PROTEIN-CODING RNA; POLYMERASE-III; H19; GENE; CELL-PROLIFERATION; TARGETED THERAPY;

D O I：

10.1186/1476-4598-10-38

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.

引用

页数：17

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