Detecting genotype x age interaction

被引：15

作者：

Almasy, L

Towne, B

Peterson, C

Blangero, J

机构：

[1] SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78245 USA

[2] Wright State Univ, Sch Med, Lifespan Hlth Res Ctr, Dayton, OH 45435 USA

来源：

GENETIC EPIDEMIOLOGY | 2001年 / 21卷

关键词：

gene x environment interaction; linkage methods; quantitative trait; statistical genetics; variance components;

D O I：

10.1002/gepi.2001.21.s1.s819

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This paper explores several extensions to the variance component method, which incorporate genotype x age interaction effects. We evaluate the performance of these methods for detecting genotypexage interaction in quantitative genetic analyses of a quantitative trait (Q4), contrasting this with false positive detection rates obtained from a phenotype influenced by the same genes but without genotype x age interaction effects (Q3). We then assess the impact on linkage power and false positive rate of allowing a QTL-specific genotype x age interaction in linkage analysis of these same traits. (C) 2001 Wiley-Liss, Inc.

引用

页码：S819 / S824

页数：6