STAT dynamics

被引：51

作者：

Reich, Nancy C. ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2007年 / 18卷 / 5-6期

关键词：

nuclear import; tyrosine phosphorylation; transcription factor; DNA binding;

D O I：

10.1016/j.cytogfr.2007.06.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of transcription factors to gain entrance to the nucleus is critical to their role in gene expression. Signal transducers and activators of transcription (STATs) are latent DNA binding factors activated by specific tyrosine phosphorylation. There are seven mammalian STAY genes encoding proteins that display constitutive nuclear localization and/or conditional nuclear localization. This review will focus on STAT I and STAT2 that are activated in response to interferon and exhibit conditional nuclear localization. The dynamic redistribution of STAT1 and STAT2 between the cytoplasm and the nucleus is coordinate with their gain of ability to bind DNA. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：511 / 518

页数：8

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