Dextran sulfate sodium-induced colitis-associated neoplasia: a promising model for the development of chemopreventive interventions

被引:146
作者
Clapper, Margie Lee
Cooper, Harry Stanley
Chang, Wen-Chi Lee
机构
[1] Fox Chase Canc Ctr, Div Populat Sci, Philadelphia, PA 19111 USA
[2] Fox Chase Canc Ctr, Div Med Sci, Philadelphia, PA 19111 USA
关键词
colorectal colitis; chemoprevention; dextran sulfate sodium; mouse models;
D O I
10.1111/j.1745-7254.2007.00695.x
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Individuals diagnosed with ulcerative colitis face a significantly increased risk of developing colorectal dysplasia and cancer during their lifetime. To date, little attention has been given to the development of a chemopreventive intervention for this high-risk population. The mouse model of dextran sulfate sodium (DSS) -induced colitis represents an excellent preclinical system in which to both characterize the molecular events required for tumor formation in the presence of inflammation and assess the ability of select agents to inhibit this process. Cyclic administration of DSS in drinking water results in the establishment of chronic colitis and the development of colorectal dysplasias and cancers with pathological features that resemble those of human colitis-associated neoplasia. The incidence and multiplicity of lesions observed varies depending on the mouse strain used (ie, Swiss Webster, C57BL/6J, CBA, ICR) and the dose (0.7%-5.0%) and schedule (1-15 cycles with or without a subsequent recovery period) of DSS. The incidence of neoplasia can be increased and its progression to invasive cancer accelerated significantly by administering DSS in combination with a known colon carcinogen (azoxymethane (AOM), 2-amino-3-meth ylimidazo[4,5-f]quinoline (IQ), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)) or iron. More recent induction of colitis-associated neoplasia in genetically defined mouse strains has provided new insight into the role of specific genes (ie, adenomatous polyposis coli (Apc), p53, inducible nitric oxide synthase (iNOS), Msh2) in the development of colitis-associated neoplasias. Emerging data from chemopreventive intervention studies document the efficacy of several agents in inhibiting DSS-induced neoplasia and provide great promise that colitis-associated colorectal neoplasia is a preventable disease.
引用
收藏
页码:1450 / 1459
页数:10
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