Conditionally MYC:insights from novel transgenic models

被引：33

作者：

Arvanitis, C

Felsher, DW

机构：

[1] Stanford Univ, Sch Med, Dept Med, Div Oncol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Pathol, Div Oncol, Stanford, CA 94305 USA

来源：

CANCER LETTERS | 2005年 / 226卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.canlet.2004.10.043

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

MYC was one of the first oncogenes identified to be associated with chromosomal aberrations and one of the most common oncogenes involved in the pathogenesis of cancer. However, until recently it was not clear if MYC would be a good target for the treatment of cancer. New conditional transgenic models have been used to demonstrate that even the brief inactivation of MYC can reverse tumorigenesis. Here we review results from recent experimental model systems, which demonstrate than the inactivation of MYC may be a specific and effective treatment for many types of cancer. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：95 / 99

页数：5

共 38 条

[1]

THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE [J].