Novel sulfonate derivatives: Potent antimitotic agents

被引：27

作者：

Gwaltney, SL ^{[1
]}

Imade, HM ^{[1
]}

Li, Q ^{[1
]}

Gehrke, L ^{[1
]}

Credo, RB ^{[1
]}

Warner, RB ^{[1
]}

Lee, JY ^{[1
]}

Kovar, P ^{[1
]}

Frost, D ^{[1
]}

Ng, SC ^{[1
]}

Sham, HL ^{[1
]}

机构：

[1] Abbott Labs, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(01)00279-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported, Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+)cancer cells, which are resistant to many other antitumor agents. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1671 / 1673

页数：3

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