The risk of using baboons as transplant donors - Exogenous and endogenous viruses

被引:25
作者
Allan, JS [1 ]
机构
[1] SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78227 USA
来源
XENOTRANSPLANTATION: SCIENTIFIC FRONTIERS AND PUBLIC POLICY | 1998年 / 862卷
关键词
D O I
10.1111/j.1749-6632.1998.tb09120.x
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
African nonhuman primates harbor several exogenous and endogenous retroviruses which deserve further consideration in the transplant setting. In particular, simian foamy viruses (SFV), simian T-cell lymphotropic virus (STLV), baboon endogenous virus (BaEV), and simian endogenous retrovirus (SERV) are all carried by baboons and may be transmitted to humans by transplantation. We have found baboons to have high seroprevalence rates to both SFV and STLV, and molecular and serologic methods have been developed to detect such agents. In addition, current nonhuman primate breeding programs have thus far not focused on eliminating these viruses. In summary, the close genetic relationship with humans and number of persistent viral infections in baboons translates into a much greater infectious disease risk when compared to that of other domesticated species.
引用
收藏
页码:87 / 99
页数:13
相关论文
共 76 条
[1]   Silk purse or sow's ear [J].
Allan, J .
NATURE MEDICINE, 1997, 3 (03) :275-276
[2]  
Allan Jonathan S, 1996, Sci Eng Ethics, V2, P486, DOI 10.1007/BF02583936
[3]  
Allan Jonathan S., 1995, ILAR J, V37, P37
[4]   Xenotransplantation at a crossroads: Prevention versus progress [J].
Allan, JS .
NATURE MEDICINE, 1996, 2 (01) :18-21
[5]   Amplification of simian retroviral sequences from human recipients of baboon liver transplants [J].
Allan, JS ;
Broussard, SR ;
Michaels, MG ;
Starzl, TE ;
Leighton, KL ;
Whitehead, EM ;
Comuzzie, AG ;
Lanford, RE ;
Leland, MM ;
Switzer, WM ;
Heneine, W .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (10) :821-824
[6]  
ALLAN JS, 1996, MOL DIAGN, V1, P1
[7]   Xenogeneic transplantation [J].
Auchincloss, H ;
Sachs, DH .
ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :433-470
[8]   Uncertainty in xenotransplantation: Individual benefit versus collective risk [J].
Bach, FH ;
Fishman, JA ;
Daniels, N ;
Proimos, J ;
Anderson, B ;
Carpenter, CB ;
Forrow, L ;
Robson, SC ;
Fineberg, HV .
NATURE MEDICINE, 1998, 4 (02) :141-144
[9]   Survival following orthotopic cardiac xenotransplantation between juvenile baboon recipients and concordant and discordant donor species: Foundation for clinical trials [J].
Bailey, LL ;
Gundry, SR .
WORLD JOURNAL OF SURGERY, 1997, 21 (09) :943-950
[10]   INFECTIOUS C-TYPE VIRUS ISOLATED FROM A BABOON PLACENTA [J].
BENVENISTE, RE ;
LIEBER, MM ;
LIVINGSTON, DM ;
SHERR, CJ ;
TODARO, GJ ;
KALTER, SS .
NATURE, 1974, 248 (5443) :17-20