Molecular biology of nickel carcinogenesis

被引：27

作者：

Costa, M ^{[1
]}

Sutherland, JE ^{[1
]}

Peng, W ^{[1
]}

Salnikow, K ^{[1
]}

Broday, L ^{[1
]}

Kluz, T ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Environm Med, New York, NY 10016 USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2001年 / 222卷 / 1-2期

关键词：

nickel carcinogenesis; molecular mechanisms; gene silencing;

D O I：

10.1023/A:1017978500031

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A review of the molecular mechanisms of nickel carcinogenesis has been compiled. This work is based upon approximately 20 years of research conducted in my laboratory. Molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel, both soluble and insoluble particles in cells, its dissolution and its effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing in cells by DNA hypermethylation in mammalian cells and by inhibiting histone acetylation in yeast cells are also discussed.

引用

页码：205 / 211

页数：7

共 25 条

[1] CYTOPLASMIC DISSOLUTION OF PHAGOCYTIZED CRYSTALLINE NICKEL SULFIDE PARTICLES - A PREREQUISITE FOR NUCLEAR UPTAKE OF NICKEL [J].

ABBRACCHIO, MP ;

SIMMONSHANSEN, J ;

COSTA, M .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1982, 9 (04) :663-676

[2] THE PHAGOCYTOSIS AND TRANSFORMING ACTIVITY OF CRYSTALLINE METAL SULFIDE PARTICLES ARE RELATED TO THEIR NEGATIVE SURFACE-CHARGE [J].

ABBRACCHIO, MP ;

HECK, JD ;

COSTA, M .

CARCINOGENESIS, 1982, 3 (02) :175-180

[3]

[Anonymous], 1990, IARC Monogr Eval Carcinog Risks Hum, V49, P1

[4] Nickel enhances telomeric silencing in Saccharomyces cerevisiae [J].

Broday, L ;

Cai, J ;

Costa, M .

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 1999, 440 (02) :121-130

[5]

Broday L, 2000, CANCER RES, V60, P238

[6] EFFECT OF MAGNESIUM ON NICKEL-INDUCED GENOTOXICITY AND CELL-TRANSFORMATION [J].

CONWAY, K ;

WANG, XW ;

XU, LS ;

COSTA, M .

CARCINOGENESIS, 1987, 8 (08) :1115-1121

[7] SEQUENTIAL EVENTS IN THE INDUCTION OF TRANSFORMATION IN CELL-CULTURE BY SPECIFIC NICKEL COMPOUNDS [J].

COSTA, M .

BIOLOGICAL TRACE ELEMENT RESEARCH, 1983, 5 (4-5) :285-295

[8]

COSTA M, 1980, CANCER RES, V40, P2688

[9]

COSTA M, 1981, CANCER RES, V41, P2868

[10]

Costa M., 1995, TOXICOL ENVIRON CHEM, V49, P145

← 1 2 3 →