Asymmetric organocatalytic cascade Michael/hemiketalization/retro-Henry reaction of β,γ-unsaturated ketoesters with α-nitroketones

被引：65

作者：

Gao, Yaojun ^{[1
]}

Ren, Qiao ^{[1
]}

Siau, Woon-Yew ^{[1
]}

Wang, Jian ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 20期

关键词：

FRIEDEL-CRAFTS ALKYLATION; C-H BONDS; ENANTIOSELECTIVE ADDITION; KINETIC RESOLUTION; MICHAEL ADDITION; CATALYSIS; DESYMMETRIZATION; COMPLEXES; THIOLS; ESTERS;

D O I：

10.1039/c1cc11124h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unprecedented enantioselective organocatalytic Michael/hemiketalization/retro-Henry cascade sequence is described, which catalyzed by a simple bifunctional indane amine-thiourea catalyst. This process provides a new route to the enantioselective synthesis of 5-nitro-pent-2-enoates, a precursor to alpha-ketolactam.

引用

页码：5819 / 5821

页数：3

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