Helping science to succeed:: improving processes in R&D

被引:29
作者
Sewing, Andreas [1 ]
Winchester, Toby [1 ]
Carnell, Pauline [1 ]
Hampton, David [2 ]
Keighley, Wilma [1 ]
机构
[1] Pfizer Global Res & Dev, Exploratory Med Sci, Sandwich CT13 9NJ, Kent, England
[2] Rath & Strong Management Consultants, Farnborough GU14 7TE, Hants, England
关键词
D O I
10.1016/j.drudis.2007.11.011
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Bringing drugs to the market remains a costly and, until now, often unpredictable challenge. Although understanding the underlying science is key to further progress, our imperfect knowledge of disease and complex biological systems leaves excellence in execution as the most tangible lever to sustain our serendipitous approach to drug discovery. The problems encountered in pharmaceutical R&D are not unique, but to learn from other industries it is important to recognise similarity, rather than differences, and to advance industrialisation of R&D beyond technology and automation. Tools like Lean and Six Sigma, already applied to increase business excellence across diverse organisations, can equally be introduced to pharmaceutical R&D and offer the potential to transform operations without large-scale investment.
引用
收藏
页码:227 / 233
页数:7
相关论文
共 27 条
[1]  
Alanine A, 2003, COMB CHEM HIGH T SCR, V6, P51
[2]  
Caldwell Gary W., 2001, Current Topics in Medicinal Chemistry, V1, P353, DOI 10.2174/1568026013394949
[3]   Outsourcing lead optimisation - the quiet revolution [J].
Clark, DE ;
Newton, CG .
DRUG DISCOVERY TODAY, 2004, 9 (11) :492-500
[4]   Components of successful lead generation [J].
Davis, AM ;
Keeling, DJ ;
Steele, J ;
Tomkinson, NP ;
Tinker, AC .
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2005, 5 (04) :421-439
[5]   Profiling drug-like properties in discovery research [J].
Di, L ;
Kerns, EH .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (03) :402-408
[6]   Lab-on-a-chip: microfluidics in drug discovery [J].
Dittrich, PS ;
Manz, A .
NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (03) :210-218
[7]   Strategic trends in the drug industry [J].
Drews, J .
DRUG DISCOVERY TODAY, 2003, 8 (09) :411-420
[8]   The industrialization of drug discovery [J].
Handen, JS .
DRUG DISCOVERY TODAY, 2002, 7 (02) :83-85
[9]  
Hirano H., 1995, 5 PILLARS VISUAL WOR
[10]   Lean and Six Sigma: Not for amateurs - Second in a 2-part series [J].
Jacobson, JM ;
Johnson, ME .
LABMEDICINE, 2006, 37 (03) :140-145