Animal models of depression and anxiety: What do they tell us about human condition?

被引：107

作者：

Neumann, I. D. ^{[2
]}

Wegener, G. ^{[3
]}

Homberg, J. R. ^{[6
]}

Cohen, H. ^{[4
]}

Slattery, D. A. ^{[2
]}

Zohar, J. ^{[5
]}

Olivier, J. D. A. ^{[7
]}

Mathe, A. A. ^{[1
]}

机构：

[1] Karolinska Univ, Huddinge Hosp, Karolinska Inst, SE-14186 Stockholm, Sweden

[2] Univ Regensburg, Dept Behav Neuroendocrinol, Fac Biol & Preclin Med, Regensburg, Germany

[3] Aarhus Univ, Ctr Psychiat Res, Aarhus, Denmark

[4] Ben Gurion Univ Negev, State Israel Minist Hlth, Fac Hlth Sci, IL-84105 Beer Sheva, Israel

[5] Tel Aviv Univ, Div Psychiat, State Israel Minist Hlth, Chaim Sheba Med Ctr,Sackler Med Sch, Ramat Gan, Israel

[6] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Neurosci, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands

[7] Radboud Univ Nijmegen, NCMLS, Dept Mol Anim Physiol, NL-6525 ED Nijmegen, Netherlands

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2011年 / 35卷 / 06期

基金：

英国医学研究理事会;

关键词：

Animal models; Anxiety; Depression; PTSD; Translational; FLINDERS SENSITIVE LINE; CORTICOTROPIN-RELEASING HORMONE; SEROTONIN TRANSPORTER GENE; PITUITARY-ADRENAL AXIS; NEUROPEPTIDE-Y CONCENTRATIONS; POSTTRAUMATIC-STRESS-DISORDER; NEUROTROPHIC FACTOR BDNF; CHRONIC MILD STRESS; COMBINED DEXAMETHASONE/CRH TEST; GROOMING ANALYSIS ALGORITHM;

D O I：

10.1016/j.pnpbp.2010.11.028

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

While modern neurobiology methods are necessary they are not sufficient to elucidate etiology and pathophysiology of affective disorders and develop new treatments. Achievement of these goals is contingent on applying cutting edge methods on appropriate disease models. In this review, the authors present four rodent models with good face-, construct-, and predictive-validity: the Flinders Sensitive rat line (FSL); the genetically "anxious" High Anxiety-like Behavior (HAB) line; the serotonin transporter knockout 5-HTT-/- rat and mouse lines; and the post-traumatic stress disorder (PTSD) model induced by exposure to predator scent, that they have employed to investigate the nature of depression and anxiety. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1357 / 1375

页数：19

共 252 条

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