Transcription factor RORα is critical for nuocyte development

被引：469

作者：

Wong, See Heng ^{[1
]}

Walker, Jennifer A. ^{[1
]}

Jolin, Helen E. ^{[1
]}

Drynan, Lesley F. ^{[1
]}

Hams, Emily ^{[2
]}

Camelo, Ana ^{[1
]}

Barlow, Jillian L. ^{[1
]}

Neill, Daniel R. ^{[1
]}

Panova, Veera ^{[1
]}

Koch, Ute

Radtke, Freddy ^{[3
]}

Hardman, Clare S. ^{[1
]}

Hwang, You Yi ^{[1
]}

Fallon, Padraic G. ^{[2
,4
,5
]}

McKenzie, Andrew N. J. ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[2] Trinity Coll Dublin, Inst Mol Med, Sch Med, Dublin, Ireland

[3] Ecole Polytech Fed Lausanne, Inst Suisse Rech Expt Canc, Lausanne, Switzerland

[4] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Med, Dublin, Ireland

[5] Our Ladys Childrens Hosp, Natl Childrens Res Ctr, Dublin, Ireland

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 03期

基金：

爱尔兰科学基金会; 英国医学研究理事会;

关键词：

INNATE LYMPHOID-CELLS; DELTA-LIKE; 4; T-CELLS; GAMMA-T; DENDRITIC CELLS; RECEPTOR-ALPHA; STEM-CELLS; NOTCH; DIFFERENTIATION; IL-4;

D O I：

10.1038/ni.2208

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for development in vitro. Pro-T cell progenitors at double-negative stage 1 (DN1) and DN2 maintained nuocyte potential in vitro, although the thymus was not essential for nuocyte development. Notably, the transcription factor ROR alpha was critical for the development of nuocytes and their role in the expulsion of parasitic worms.

引用

收藏

页码：229 / U43

页数：9

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