NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection

被引:16
作者
Bennett, AD
Taglialatela, G
Perez-Polo, R
Hulsebosch, CE
机构
[1] Univ Texas, Med Branch, Inst Marine Biomed, Galveston, TX 77555 USA
[2] Univ Texas, Med Branch, Dept Anat & Neurosci, Galveston, TX 77555 USA
[3] Univ Texas, Med Branch, Dept Human Biol, Galveston, TX 77555 USA
关键词
dorsal root ganglia; nerve growth factor; NGF; rat; spinal cord injury; neurotrophin; neurotropin;
D O I
10.1097/00001756-199903170-00040
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
TO examine changes in nerve growth factor (NGF) levels in spinal cord and dorsal root ganglia (DRG) after spinal injury, male Sprague-Dawley rats weighing 150-175 g were given spinal hemisections. NGF content was measured at various post-surgical times and compared with naive controls (n = 4 per time point) in the spinal cord, DRG and blood serum by ELISA techniques (Promega). Levels of NGF in the blood serum were significantly increased 8-fold at 48 h but were significantly decreased in the spinal cord and DRG by 2- to 4-fold until 7 days postsurgery (ANOVA, p<0.05). Contrary to accepted dogma, spinal injury results in decreased levels of NGF in the spinal cord and DRG following spinal injury. NeuroReport 10:889-893 (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:889 / 893
页数:5
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