Synthesis and structure of a macrocyclic europium complex and its possible role as a catalyst for phosphodiester transesterification

被引：21

作者：

Haner, R ^{[1
]}

Hall, J ^{[1
]}

Rihs, G ^{[1
]}

机构：

[1] CIBA GEIGY AG, CENT SERV, CH-4002 BASEL, SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1997年 / 80卷 / 02期

关键词：

2,2'-6',2''-TERPYRIDINE MACROCYCLES; ANTISENSE OLIGONUCLEOTIDES; COORDINATION CHEMISTRY; SELECTIVE HYDROLYSIS; LANTHANIDE IONS; RNA;

D O I：

10.1002/hlca.19970800213

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and X-ray crystal structure of a europium macrocyclic complex 1, an important catalyst used for the sequence-specific cleavage of RNA, is reported. The role of this metal complex in facilitating phosphate transesterification is discussed.

引用

页码：487 / 494

页数：8

共 23 条

[1] LANTHANIDE(III) TETRAAMIDE MACROCYCLIC COMPLEXES AS SYNTHETIC RIBONUCLEASES - STRUCTURE AND CATALYTIC PROPERTIES OF [LA(TCMC)(CF3SO3)(ETOH)](CF3SO3)(2) [J].