Dendritic Actin Filament Nucleation Causes Traveling Waves and Patches

被引：56

作者：

Carlsson, Anders E. ^{[1
]}

机构：

[1] Washington Univ, Dept Phys, St Louis, MO 63130 USA

来源：

PHYSICAL REVIEW LETTERS | 2010年 / 104卷 / 22期

基金：

美国国家卫生研究院;

关键词：

ARP2/3; COMPLEX; CELL LOCOMOTION; MOTILITY; NETWORKS; DICTYOSTELIUM; CYTOSKELETON; OSCILLATIONS; PROTEINS;

D O I：

10.1103/PhysRevLett.104.228102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The polymerization of actin via branching at a cell membrane containing nucleation-promoting factors is simulated using a stochastic-growth methodology. The polymerized-actin distribution displays three types of behavior: (a) traveling waves, (b) moving patches, and (c) random fluctuations. Increasing actin concentration causes a transition from patches to waves. The waves and patches move by a treadmilling mechanism not involving myosin II. The effects of downregulation of key proteins on actin wave behavior are evaluated.

引用

页数：4

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